Choice of serum markers in antenatal screening for Down's syndrome.
نویسندگان
چکیده
منابع مشابه
Chronic constipation in long stay
syndrome. In: Grudzinskas JG, Chard T, Chapman M, Cuckle HS, eds. Cambridge: Cambridge University Press, 1993 (in press). 25 Laundon C, Spencer K, Macri JN, Buchanan P. Tumer syndrome detection by MSAFP/Free Beta (hCG) screening. J Med Genet 1993;30:340-1. 26 Spencer K, Mallard AS, Coombes EJ, Macri JN. Prenatal screening for trisomy 18 with free f3 human chorionic gonadotrophin. BMJ 1993 (in p...
متن کاملThe role of maternal serum alpha-fetoprotein, human chorionic gonadotrophin and oestriol in the antenatal screening of Down's syndrome.
The use of maternal age alone to identify pregnant mothers at risk of a fetus with Down's syndrome has recently been supplemented by maternal serum screening using biochemical markers such as alpha-protein, human chorionic gonadotrophin and oestriol. These tests have been reported to increase the sensitivity of antenatal detection of such fetuses from 35% to 67% with a false positive rate of 5%...
متن کاملAn update on antenatal screening for Down's syndrome and specific implications for assisted reproduction pregnancies.
Since the introduction of antenatal serum screening for Down's syndrome (DS) more than two decades ago, several screening approaches have been utilized in routine clinical practice. The current DS screening strategies involve mid-trimester serum biochemistry tests, first trimester tests combining sonographic markers and serum biochemistry and integration of first and second trimester markers. I...
متن کاملAntenatal maternal serum screening for Down's syndrome: results of a demonstration project.
OBJECTIVES To assess the implementation of antenatal screening for Down's syndrome in practice, using individual risk estimates based on maternal age and the three serum markers: alpha fetoprotein, unconjugated oestriol, and human chorionic gonadotrophin. DESIGN Demonstration project of Down's syndrome screening; women with a risk estimate at term of 1 in 250 or greater were classified as "sc...
متن کاملAntenatal screening for Down's syndrome with the quadruple test.
Second trimester screening for Down's syndrome is widely practised throughout the world. We assessed the performance of antenatal serum screening for Down's syndrome with the quadruple test in 46193 pregnancies from 14 hospitals over 5 years. Women who screened positive (risk > or =1 in 300) were offered diagnostic amniocentesis or chorionic villus sampling. Of 88 observed Down's syndrome pregn...
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ورودعنوان ژورنال:
- Journal of medical screening
دوره 1 2 شماره
صفحات -
تاریخ انتشار 1994